Prof. Dr. Shu-Ming Li
Pharmacy
Pharmaceutical Biology and Biotechnology
Robert-Koch-Str. 4, 35037 Marburg
+49-6421 28 22461
shuming.li@staff.uni-marburg.de
Research Area
The main focus of Li lab is the functional genomics of secondary metabolites in microorganisms, especially in fungi of ascomycetes and bacteria of actinomycetes. The most interested substances are polyketides, cyclodipeptide derivatives and prenylated natural products.
Further research interests are chemoenzymatic biosynthesis and synthetic microbiological approaches for production of biologically active compounds.
Expertise
synthetic microbiology
actinomycetes genetics
fungal genetics
site-directed mutagensis
biochemistry and enzymology
natural product biosynthesis
isolation and analysis of microbial metabolites
structural elucidation of low-molecular compounds
Recent Publications, Last 3 Years
1. Liao G, Mai P, Fan J, Zocher Z, Stehle T, Li S-M (2018) Complete decoration of the indolyl residue of tryptophan-containing cyclic dipeptides with geranyl moieties via protein engineering. Org Lett 20: 7201– 7205.
2. Liu J, Xie X, Li S-M (2019) Guanitrypmycin biosynthetic pathways imply cytochrome P450-mediated regio- and stereospecific guaninyl transfer reactions. Angew Chem Intern Ed 58: 11534-11540.
3. Fan J, Liao G, Kindinger F, Ludwig-Radtke L, Yin W-B, Li S-M (2019) Peniphenone and penilactone formation in Penicillium crustosum via 1,4-Michael additions of ortho-quinone methide from hydroxyclavatol to γ-butyrolactones from crustosic acid. J Amer Chem Soc 141: 4225–4229.
© 2016