Andreas Diepold

Andreas Diepold

Dr. Andreas Diepold

Max Planck Institute for Terrestrial Microbiology
Department of Ecophysiology
Karl-von-Frisch-Str. 10, 35043 Marburg
+49-6421 178 302
andreas.diepold@mpi-marburg.mpg.de

Research Area

The Diepold lab studies the molecular function and regulation of the type III secretion system, a nano-syringe used by bacteria to manipulate eukaryotic host cells. In particular, we want to understand how protein secretion is activated, precisely adapted and stopped by external signals, and how these mechanisms enable bacteria to successfully establish an infection. We found that function and regulation of the T3SS require active remodelling of the system, and our lab follows these dynamic processes in live bacteria, in real time, from the single-molecule level up to cellular host-pathogen interactions. Using synthetic biology approaches, we aim to control and apply the T3SS for biotech and healthcare.

Expertise

fluorescence microscopy
protein dynamics
microbe-host interactions
optogenetics
membrane transport
infection biology
microbial genetics
bacterial cell biology

Recent Publications, Last 3 Years

1. Milne-Davies B, Helbig C, Wimmi S, Cheng DWC, Paczia N & Diepold A (2019) Life After Secretion—Yersinia enterocolitica Rapidly Toggles Effector Secretion and Can Resume Cell Division in Response to Changing External Conditions. Front. Microbiol. 10: 2128

2. Diepold A (2019) Assembly and Post-assembly Turnover and Dynamics in the Type III Secretion System. Current topics in microbiology and immunology, doi: 10.1007/82_2019_164

3. Diepold A, Sezgin E, Huseyin M, Mortimer T, Eggeling C & Armitage JP (2017) A dynamic and adaptive network of cytosolic interactions governs protein export by the T3SS injectisome. Nat. Commun. 8: 15940

https://www.mpi-marburg.mpg.de/diepold

SYNMIKRO Young Researchers Groups

Almost all scientific members of SYNMIKRO are actively involved in DFG’s Collaborative Research Centers (Sonderforschungsbereiche), Research Training Groups (Graduiertenkollegs), or other Cooperative Research projects. Alongside performing adventurous experiments, and reporting excellent science, SYNMIKRO substantially promotes potential Young Research Group Leaders by constantly keeping its doors open to welcome and support Young Researchers planning to set up an Independent Research Group.
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