Hans-Ulrich Mösch

Research Area

The Mösch lab studies the molecular mechanisms underlying fungal development and pathogenesis. At the example of apathogenic and human pathogenic yeasts, we investigate the molecular and structural basis of cell adhesion, cell wall biogenesis, signal transduction and transcriptional regulation. Our goal is to understand how environmental adaptation and evolution of these processes contribute to the ability of microbes to choose between different lifestyles and colonize diverse ecological niches.

Expertise

Microbial development
Fungal adhesion
Cell wall biogenesis
Microbe-host interaction
Intracellular signaling
Transcriptional regulation
Protein-glycan interaction
Yeast molecular genetics

Recent Publications

1. Brückner S, Schubert R, Kraushaar T, Hartmann R, Hoffmann D, Jelli E, Drescher K, Müller DJ, Essen LO, Mösch HU (2020) Kin discrimination in social yeast is mediated by cell surface receptors of the Flo11 adhesin family. Elife 9: e55587

2. Hoffmann D, Diderrich R, Reithofer V, Friederichs S, Kock M, Essen LO, Mösch HU (2020) Functional reprogramming of Candida glabrata epithelial adhesins: the role of conserved and variable structural motifs in ligand binding. J Biol Chem 295: 12512-12524

3. Vogt MS, Schmitz GF, Varón Silva D, Mösch HU, Essen LO (2020) Structural base for the transfer of GPI-anchored glycoproteins into fungal cell walls. Proc Natl Acad Sci USA 117: 22061-22067

https://www.uni-marburg.de/en/fb17/disciplines/genetics/group-moesch