Philipps University Marburg
Department of Biology
Laboratory for Molecular Microbiology
+49-6421 28 1529
The development of the cytoplasmic membrane was a key event in the evolution of microbial cells as it created a protected reaction chamber for the performance of life’s vital attributes. However, it also generated a severe problem for microbial cells because this biochemical reaction chamber with its high concentrations of nucleic acids, proteins, organic metabolites and inorganic ions possesses a high osmotic potential. This makes the microbial cell vulnerable to changes in environmental osmolarity as these will inevitably trigger water fluxes across the semi-permeable cytoplasmic membrane, causing either dehydration of the cytoplasm (upon sudden or sustained exposure to high osmolarity), or cell rupture (upon sudden exposure to low osmolarity). The Bremer group studies the genetics, physiology, and molecular biology of the cellular adjustment responses of microorganisms, in particular of Bacillus subtilis, to osmotic stress.
Genomics and transcriptomics
Analytics of metabolites
Uses of compatible solutes
1. Mais C-N, Hermann L, Altegoer F, Seubert A, Richter AA, Wernersbach I, Czech L, Bremer E, Bange, G (2020) Degradation of the microbial stress protectants and chemical chaperones ectoine and hydroxyectoine by a bacterial hydrolase-deacetylase complex. J Biol Chem 295: 9087-9104.
2. Czech L, Höppner A., Kobus S, Seubert A, Riclea R, Dickschat JS, Heider J, Smits HJS, Bremer, E (2019) Illuminating the catalytic core of ectoine synthase through structural and biochemical analysis. Sci Rep 9:364.
3. Hoffmann T, Warmbold B, Smits SHJ, Tschapek B, Ronzheimer S, Bashir A, Chen, C, Rolbetzki A, Pittelkow M, Jebbar M, Seubert A, Schmitt L, Bremer E (2018) Arsenobetaine: an ecophysiological important organoarsenical confers cytoprotection against osmotic stress and growth temperature extremes. Env Microbiol 20: 305-323.