The overall goal of our research is to unravel the mechanisms that allow bacteria to adapt and differentiate in response to changes in the environment. Bacteria have evolved several strategies that allow them to cope with such changes including changes in gene expression ranging from changes in the expression of relatively few genes to changes in the expression of large numbers of genes culminating in cell differentiation, changes in the motility behavior of cells, and changes to the cell cycle. To implement these strategies bacterial cells have to process vast amounts of information and then generate the appropriate output response(s). Information processing is carried out by complex networks of signal transduction proteins. We try to understand how these networks are organized in space and time to allow the ordered execution of various tasks.
Bacterial cell cycle
Bacterial signal transduction
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